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Abstract The Biorepository and Integrative Genomics (BIG) Initiative in Tennessee has developed a pioneering resource to address gaps in genomic research by linking genomic, phenotypic, and environmental data from a diverse Mid-South population, including underrepresented groups. We analyzed 13,152 exomes from BIG and found significant genetic diversity, with 50% of participants inferred to have non-European or several types of admixed ancestry. Ancestry within the BIG cohort is stratified, with distinct geographic and demographic patterns, as African ancestry is more common in urban areas, while European ancestry is more common in suburban regions. We observe ancestry-specific rates of novel genetic variants, which are enriched for functional or clinical relevance. Disease prevalence analysis linked ancestry and environmental factors, showing higher odds ratios for asthma and obesity in minority groups, particularly in the urban area. Finally, we observe discrepancies between self-reported race and genetic ancestry, with related individuals self-identifying in differing racial categories. These findings underscore the limitations of race as a biomedical variable. BIG has proven to be an effective model for community-centered precision medicine. We integrated genomics education, and fostered great trust among the contributing communities. Future goals include cohort expansion, and enhanced genomic analysis, to ensure equitable healthcare outcomes. 

Recently, with the advent of the Internet of everything and 5G network, the amount of data generated by various edge scenarios such as autonomous vehicles, smart industry, 4K/8K, virtual reality (VR), augmented reality (AR), etc., has greatly exploded. All these trends significantly brought real-time, hardware dependence, low power consumption, and security requirements to the facilities, and rapidly popularized edge computing. Meanwhile, artificial intelligence (AI) workloads also changed the computing paradigm from cloud services to mobile applications dramatically. Different from wide deployment and sufficient study of AI in the cloud or mobile platforms, AI workload performance and their resource impact on edges have not been well understood yet. There lacks an in-depth analysis and comparison of their advantages, limitations, performance, and resource consumptions in an edge environment. In this paper, we perform a comprehensive study of representative AI workloads on edge platforms. We first conduct a summary of modern edge hardware and popular AI workloads. Then we quantitatively evaluate three categories (i.e., classification, image-to-image, and segmentation) of the most popular and widely used AI applications in realistic edge environments based on Raspberry Pi, Nvidia TX2, etc. We find that interaction between hardware and neural network models incurs non-negligible impact and overhead on AI workloads at edges. Our experiments show that performance variation and difference in resource footprint limit availability of certain types of workloads and their algorithms for edge platforms, and users need to select appropriate workload, model, and algorithm based on requirements and characteristics of edge environments. 

Within cells, cytoskeletal filaments are often arranged into loosely aligned bundles. These fibrous bundles are dense enough to exhibit a certain regularity and mean direction, however, their packing is not sufficient to impose a symmetry between—or specific shape on—individual filaments. This intermediate regularity is computationally difficult to handle because individual filaments have a certain directional freedom, however, the filament densities are not well segmented from each other (especially in the presence of noise, such as in cryo-electron tomography). In this paper, we develop a dynamic programming-based framework, Spaghetti Tracer, to characterizing the structural arrangement of filaments in the challenging 3D maps of subcellular components. Assuming that the tomogram can be rotated such that the filaments are oriented in a mean direction, the proposed framework first identifies local seed points for candidate filament segments, which are then grown from the seeds using a dynamic programming algorithm. We validate various algorithmic variations of our framework on simulated tomograms that closely mimic the noise and appearance of experimental maps. As we know the ground truth in the simulated tomograms, the statistical analysis consisting of precision, recall, and F1 scores allows us to optimize the performance of this new approach. We find that a bipyramidal accumulation scheme for path density is superior to straight-line accumulation. In addition, the multiplication of forward and backward path densities provides for an efficient filter that lifts the filament density above the noise level. Resulting from our tests is a robust method that can be expected to perform well (F1 scores 0.86–0.95) under experimental noise conditions. 

Interstitial lung disease (ILD) causes pulmonary fibrosis. The correct classification of ILD plays a crucial role in the diagnosis and treatment process. In this research work, we propose a lung nodules recognition method based on a deep convolutional neural network (DCNN) and global features, which can be used for computer-aided diagnosis (CAD) of global features of lung nodules. Firstly, a DCNN is constructed based on the characteristics and complexity of lung computerized tomography (CT) images. Then we discussed the effects of different iterations on the recognition results and influence of different model structures on the global features of lung nodules. We also incorporated the improvement of convolution kernel size, feature dimension, and network depth. Thirdly, the effects of different pooling methods, activation functions and training algorithms we proposed has been analyzed to demonstrate the advantages of the new strategy. Finally, the experimental results verify the feasibility of the proposed DCNN for CAD of global features of lung nodules, and the evaluation shown that our proposed method could achieve an outstanding results compare to state-of-arts.